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Hypertension and dyslipidemia often coexist and are well-established risk factors for cardiovascular diseases.Very few studies have directly compared losartan, telmisartan, and olmesartan for efficacy, safety, and effect on metabolic parameters such as lipid profile and blood glucose.At the same time, data supporting the same in Indian population are not substantial.There is paucity of studies showing the effect of ARBs on lipid profile in Indian population.Therefore, the present study was planned in patients of Stage I hypertension with the objectives to compare the efficacy and tolerability of losartan, telmisartan, and olmesartan as antihypertensive and to evaluate and compare the effects of losartan, telmisartan, and olmesartan on lipid profile and blood glucose.
A detail medical history was obtained and physical examination performed.
Newly diagnosed patients of Stage I hypertension of either gender with age 18 years, willing to participate, and ready to give written informed consent were included in the study.
Patients suffering from diabetes, abnormal liver or kidney function, or any other systemic illness and taking other concomitant medication including antihypertensive medication were excluded from the study.
and those who met the inclusion criteria were briefed about the study.
Patient information sheet was given to all prospective participants, and written informed consent in vernacular language was obtained from patients willing to participate.